there is no reason it shouldnt work
just make sure that your gpu has more than 3 outputs to support that much monitors
if its an AMD card you are going to have to buy an active display port adapter for the third monitor to work
eyefinity will work if they are the same resolution but its not going to look very good since your monitors are not the same size
the 26'' is going to have everything bigger and zoomed out compared to your other monitors