I going to build a pc which has phenom ii x4 955 and (am3+) mobo and i'm gonna get gtx 650 ti, so my question is : I intend to enable physx for my gaming experience, but i heard that it can't be enabled if the GPU detected AMD driver presence, would this be true w/mobo drivers or it's just if another radeon card is there ?
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PhysX is an nVidia software. You won't have any issues using it with your nVidia GPU (650ti).
It would disable it if you had a amd gpu with nvidia gpu. You will be fine.