I would recommend you look into Silverstone's cases with rotated motherboards. Several have 3 180mm fans mounted on the bottom so that a significant positive pressure is created and a significant amount of cold air is forced out the top and any other crack in the case! They have been used by manufacturers to display 3 and 4 GPU's. There are drawbacks to these cases, I have the Raven II and wish it had better HD mounting, but newer models have addressed that. I never feel anything but cold air coming out the top as there is simply no time for hot air to accumulate in the case. Cold air will flow quickly up both sides of each card and out the top. If you think about it, the tradition design, which has really not changed much in airflow design, was created when CPU's and GPU's ( if there was one ) didn't even have fans! GPU's in traditional cases are upside down and the heatsinks have to draw heat downward, against physics, to dissipate heat . Lian Li even designed a case that flips things to the other side so that the GPU is actually facing up, not a bad idea, but I still think that the fast bottom to top airflow is the best design. Tom's reviewed the Raven II about a year ago and found it best at cooling interior components compared to four other large cases. It wasn't best at everything, like noise, so do your research. I do think that large cases with very large side mounted fans can do a great job at cooling GPU's, but make sure they have top mounted fans too, as many now do, so that hot air can not be trapped anywhere in the case. Space for a large water cooler should be a significant concern if you are sure you are going to go that way, but of course it gets pricey with H2O cooling for 4 GPU's!
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