Mouse and Keyboard randomly lock up/freeze

This problem started about 3 weeks ago, While playing games my mouse and keyboard randomly lock up, all sounds and video continue to work. The only way i can get my mouse/keyboard to work again is to manually restart the machine.

What i've done

What i've yet to do

It happens the majority of the time while playing games (League of legends) and has only happened one other time, while browsing my computer, but that was shortly after exiting the game. Any help or suggestions would be greatly appreciated thank you.
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More about mouse keyboard randomly lock freeze
  1. Since you've tried another set of keyboard / mouse and did a full scan (even formatted), it could be a faulty motherboard. Are your devices connected via USB or PS2?
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