You will have to set it up to run full screen then. I run with triple monitors as well on a gtx titan and I find that if you double click on say a window like windows media player at the top it will maximize just to that screen. Hitting the maximize button though will spread it across all three displays but only show the video in one which is kind of pointless. Browser windows work normally though. Games are tougher that way so you will have to manually setup each game inside the game as either full screen or windowed mode to get what you want.