Mafia II Stuttering help?

For a few months ago i installed Mafia II on my computer. After finished the process then launched the game. At first it was good, but for a few minutes later when in the City, the game stutters. What do i mean of stuttering is like lagging, but the last frame of pic is pushed to the current frame of pic, so the picture are conflicting. I can't add in more information and get the screen pics (when used print screen, the results are normal, flawless game). Oh, and are the Mafia II PhysX Nvidia is conflicting with my Graphics Card which is AMD Radeon? And how to make it smoother?

Sorry for the minimum information. Thanks in Advance
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