Running Physx on an Nvidia GPU while running AMD gpus is totally workable with some effort, but really I don't see enough results from enough games to recommend a stand alone card for it. I don't expect to see Nvidias new cards until at least third quarter, but it seems both camps are moving faster than they said the would. One though though, the 700 series looks like it will be a rehash of both 600 series chips and Titan chips. As far as value goes, it doesn't look good. Just my 2c.