Upgrading HP Pavilion Slimline s5220f, Full Specs Included

Dear Tom's Hardware community:

I am looking to upgrade an HP Pavilion Slimline s5220f desktop by adding a GPU and possibly making other upgrades. I need it to run Blender and UDK smoothly, including the ability to smoothly test and play games made with UDK, and work with lighting, materials, and particle systems in both Blender and UDK. My primary upgrade will be adding an NVIDIA GPU, preferably one I can use for Blender Cycles (CUDA and decent VRAM). I am also open to upgrading the motherboard, RAM, and/or processor if it can be done affordably; the current motherboard only supports 4GB of RAM, so I can't upgrade RAM without replacing it. It's also a socket 775. Full system specs and the copy-pasted "how to ask" form are included below as spoilers. Please recommend any and all upgrades that you would make/that can be reasonably made (no case-modding, etc.). All input is much appreciated!

"How to ask" form
Approximate Purchase Date: Mid-June 2013

Budget Range: $200-$300, less is better, focus on value. I'm not looking to just buy a $200 GPU and call it a day.

System Usage from Most to Least Important: Blender and UDK, Light(ish) Gaming, Casual Usage

Are you buying a monitor: No

Parts to Upgrade: GPU and possibly others (PSU, motherboard, processor, RAM)

Do you need to buy OS: Maybe (using OEM license); would prefer not to

Preferred Website(s) for Parts: Newegg, Amazon, TigerDirect/CompUSA

Location: Naperville, IL, USA; I have CompUSA and Best Buy within ten minutes of my house.

Parts Preferences: NVIDIA GPU a must; prefer ASUS motherboards if replacing

Overclocking: Maybe (would like to)

SLI or Crossfire: No

Your Monitor Resolution: 1280x1024

Additional Comments: This will be my first time upgrading components; I am looking to build a combination game development/gaming rig pretty much at the same time for about $1500, but would like to upgrade this old PC to handle some more advanced software if the price is right. I am open to (safe, 24/7) overclocking as a potential upgrade option, though I have heard that OEMs take measures to prevent it in their PCs, and I have never overclocked before. Could be interesting trying to put an aftermarket cooler in my slimline case, though.

And Most Importantly, Why Are You Upgrading: Integrated graphics from 2009 = no 3D modeling ability, no 3D gaming ability. Software emulators are too slow; I need to upgrade the hardware.
Full Specs (Originally Bought – Not Built)
Model: HP Pavilion Slimline s5220f
Processor: Intel Pentium Dual-Core E5300 @ 2.60 GHz (Family 6, Model 7, Stepping A, Revision R0)
Motherboard: MSI MS-7525 Version 1.0
Chipset: Intel G31 Express, Revision 10
Memory: Samsung 2x2GB DDR2 @ 800MHz (M378T5663QZ-CF7)
GPU: None
Hard Drive: Samsung 640GB 7200RPM 16MB Cache Hard Drive (HD642JJ)
Optical Drive: HP GH40L
Power Supply: HP TFX0220D5WA 220W Power Supply
Cooler: Stock Cooler, Asia Vital Components 3B9344DC
Other PCIe Card: HP 503094-001 PCI Express x1 56 kbps data/fax modem
Note on PCIe Slot: I have measured the available room, and I can have a single-slot-width card that is 6.5" long (can't fit a 7"-long card because of DIMMs).
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