my brother recently purchased a naga hex and installed the synapse 2.0 drivers. you need to provide an email address and some other details. apparently it stores your settings on a cloud server which i dont agree with. the drivers are working fine for him right now but i've heard of bugs in the software. i was involved in a post on here trying to fix an issue with synapse.
you can use a basic mouse like a deathadder without the drivers. the windows drivers will support the extra buttons but you will lose the ability to change the glow status of the icon on the mouse and adjust the dpi. i can live without those features and since windows supports the extra buttons i can get along fine without them. its my personal choice to not use the drivers.
the deathadder is ideal for people with average sized hands who like to palm the mouse. i rest my pointer finger on the left button, ring finger on the right, 3rd finger on the top curling around to the right side and my pinky kind of drags half off the mouse. i can very easily press the two side buttons with my thumb. they have enough resistance so that you dont accidentally click them, are in a location so you can use your thumb to pick up the mouse and reset the mouse position without clicking the buttons and are large and simple enough to click without making a mistake. personally i havent found a mouse which has worked for me better. they are low profile buttons but they do stick out of the mouse between 1/32 and 1/16 of an inch. again, i've had no problems.
in short... i find the design almost perfect. the drivers work but you need to register and cloud host settings. you can use the mouse without drivers but you lose a few features.
i use it on this mousepad....
before i used to have a standard sized black mousepad.