You will want to reboot and let your computer boot with the monitor plugged into your motherboard. No other configuring should be needed. The only thing I can think of, not knowing what motherboard you have, is changing your default graphics adapter in your BIOS from PCI to integrated, but I don't have to change any settings when I use mine. I actually use mine for displaying on my TV for shows and stuff while my monitor is plugged into my GPU for all other tasks, works quite well, but i haven't tried gaming with it