Will quad channel memory work in a dual channel motherboard?

Shock0

Honorable
Apr 21, 2013
39
0
10,530
Will 4 sticks of quad channel memory (16gb) G,Skill Ripjaws 4x4 or corsair vengeance 4x4 1600 run on a dual channel motherboard (MSI
990FXA-GD80) ? i wont need more than 16 for some years so i dont care about 8 x 2 for future upgrades , is there a difference between 4x4 and 8x2 , because filling all the ram slots will look better in my opinion and 4x4 is cheaper .Also can i use 1866 in quad channel memory ? (processor fx 8350)