You will gain no significant advantage running 16 GB of single channel memory over 8 GB of dual channel memory since you pay a heavy performance penalty, forcing the system to run in single channel mode, which you will feel 100% of the time, whereas the increase in memory from 8 to 16 GB will likely not be felt except in extreme circumstances. While you can run them together, you will be ahead in memory bandwidth to stick to a matched set. Consequently, it's also very likely you'll only be able to run a single pair of memory modules at 1866 successfully, although you may find some settings through trial and error that will work for four.
Tom's did an article where they found at around the 8 GB point, you hit diminished returns...