A lot of information here:
http://www.amd.com/us/products/technologies/amd-eyefinity-technology/how-to/Pages/faqs.aspx#multiple-display-requirements
What are the basic requirements for connecting multiple displays?
Connecting multiple monitors for AMD Eyefinity technology couldn’t be simpler. There are four easy rules to remember:
1.The first two monitors can connect to the graphics card with any display output on your product: HDMI, VGA, DVI or DisplayPort.
2.The third (or greater) display must be connected to the graphics card via DisplayPort.
3.If your monitor does not have a DisplayPort connection, you will need an inexpensive active DisplayPort adapter for it. DVI to DP adapters can be had for less than $30 USD.2
4.Every family of GPUs supports a different maximum number of displays.
What if the DVI monitor I want to connect to DisplayPort uses a resolution higher than 1920x1200?
An active dual-link DVI to DisplayPort adapter is required.
How can you connect multiple monitors to a DisplayPort connector?
As previously indicated, AMD graphics solutions equipped with DisplayPort 1.2 outputs can actually run multiple monitors from a single port.
This feature is called Multi-Stream Transport, or MST, and it allows a single cable from the graphics card to carry the signal for multiple monitors. Taking advantage of this feature requires one of two things:
◾A DisplayPort 1.2 MST-capable hub, which connects to the graphics card’s DisplayPort output on one end, and provides multiple monitor connections on the other.
◾Or DisplayPort 1.2 MST-capable monitors, which allow a user to daisy chain monitors together, with the final monitor connecting to the graphics card.
Using DisplayPort 1.2 MST, a user can connect up to six displays to a single port on many AMD Radeon™ graphics and AMD FirePro™ professional graphics products.
Do I really need DisplayPort 1.2-compatible components to run six displays?
Not at all. Products like the Asus HD 7970 DirectCU II or ATI FirePro™ V9800 support up to 6 displays without any need for DisplayPort 1.2-compatible hubs or monitors. These manufacturers have designed unique solutions with additional DisplayPort outputs, which obviate the need for such equipment.
Etc.