What's the best tool ? Some might say screwdriver, some might say hammer, some might say pliers ..... but to answeer the question realistically, kinda gotta know what ya doing with it.
Not that I use Asus exclusively but the newegg combo's over the last year have been great and I really like the Sabertooth and WS features and it just gets easier dealing with the same BIOS that you are familiar with as well as tech support procedures.
For anyone except the top end enthusiast consumers I think the new MSI gd65, a mid range asrock, or one of the asus mainstream boards like the pro is the best bet.