It depends on what you mean by brackets. Even if your computer is small everything is standard as in every other PC.
Your main concern is if the card will fit in the case physically and that will depend on the card's dimension and if the card is low profile or not. A non-low profile card (which I guess is the definition of a standard card now) takes up to slots/(brackets?) in the back of the case. Low profile cards only takes up one. The best low profile card you can get your hands on is a 7750.