Is it okay to disassemble a pc for cleaning?

It's been about 8 months since I built this pc and notice it's about time for it to be cleaned.

What I want to do is to take the whole thing apart and clean each component individually. What I want to know is is it good practice to disassemble a pc? I noticed while putting it together many plugs are a very tight fit, that is they're not made to be plugged/unplugged repeatedly. While this is my first time so I think I should be okay, is it something to avoid doing more of in the future? Would this wear down the connectors in any harmful way?
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More about disassemble cleaning
  1. Anything that can be plugged in can be plugged out. As with many things, handle with care though. Don't use too much force. Disassemble slowly and look at videos if you're unsure.
  2. I blow all the cases out and clan filters quarterly..... everything gets reseated yearly. Havent really found a need to "diassemeble" ...... "No disassemble No. 5 !"
    (movie reference) anything ..... just use compressor to blow out dust and pull the card and reseat w/o actually taking outta case.
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