It is uncommon with with 1333 and below, of if don't mind running underclocked or at less than optimal, but dealing and working with DRAM every day, it even happens with older DDR2...todays DRAM is sold in so many different packages of different amounts of sticks for a reason - the sticks in a package are tested to work together, tolerances are so tight, you might pull 20 consecutive sticks out of a production lot, and only find 4 that work together and play nice to make one 4 stick set, getting 2 sticks to play nice is easier, three a little harder, 4 mentioned 6 harder and 8 hardest yet.....If it was as easy as just throwing any two sticks together as long as they had the same specs then the manufacturers would just package individual sticks and charge a little less per stick and make tons more money....the reason they don't is they would be inundated even more than they are with having to process RMAs, because people have listened to all these 'experts', tell them 'Yeah no problem, just stick another similar stick in there'......as is, of the DRAM that 'doesn't work' and is RMAed appr 80+ % has absolutely nothing wrong with it, it's from people listening to these 'experts' and mixing sticks and also listening to the 'experts' tell them they can run say 2400 sticks because it says so on the mobo ads, when they have an entry level CPU that can only run 1333....so if you ever see ANYONE telling somebody 'yeah it's fine to run those sticks' without knowing the CPU and the mobo, then it's a person who has no idea what he's talking about, most of this is just common sense.