Yes, I don't recommend ever mixing packages of DRAM (nor does anyone who knows DRAM), it's sold in packages of different numbers of sticks for a few reasons, 1) it's been tested so that all sticks work together, with tolerances as tight as they are, out of 20 sticks off a production line, you may only fine a single group of 4 that will play nice at rated specs, or you might find 2 or three sets 2) XMP is the preferred way of setting sticks up in a system and the programming is done via the packaged set, i.e. a 2 stick set may have the same base timings as a 4 stick set (say 9-9-9-27), but when installed the 2 sticks may require an advanced timing for tRFC of 128 while the same in a four stick package will require the tRFC at 208....this is something I see in these forums all the time, people telling others, to just go ahead and add more sticks, which can be easy with low freq entry level sticks like 1066 and 1333, but once you get to 1600 and up, it gets progressively harder....on occasion the BIOS can adjust things to get them running, but seldom is it optimally, and there are very few around who are comfortable going into the advanced timings to set things up...and even then, the sticks may not want to play, so then you end up having to adjust the DRAM and/or the MC voltage, and again, few who are comfortable doing so.....What it can amount to is someone who buys two sets of 2 sticks to save $5-6 over buying a single 4 sticks package may end up spending hours trying to them to work, maybe paying postage and restocking fees, or making another trip to the store to exchange whatever....