Running Two cards--1 Nvidia and 1 AMD

Solution
The GT 220 would not make a good PhysX card, not enough CUDA cores. Hybrid PhysX (AMD graphics + Nvidia PhysX) has not been supported in any drivers over the past two years anyway, although it is possible to get it to work. Best to consider running a primary Nvidia card next time.
http://physxinfo.com/wiki/Hybrid_PhysX

http://www.tomshardware.com/reviews/nvidia-physx-hack-amd-radeon,2764-8.html
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katiklysm

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Aug 11, 2010
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You aren't intended to be able to do this- though last I knew, there are some hacks and registry values that an inquiring mind could search out and find to make it work.

My take: Seems like more trouble than it's worth.
 
here is a site with info on using the latest drivers for your nvidia card for hybrid physx.

just be aware that it is not officially supported even thought nvidia would still be making money with people doing this.

www.ngohq.com/graphic-cards/22136-how-to-fix-hybrid-physx-with-latest-physx-and-geforce-285-solved.html
 
Solution

ihog

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It's not shameless. It's just a lot easier to run PhysX with all nVidia cards.