manofchalk :
You wont be able to run PhysX off an AMD card, but you can still install PhysX drivers and run it off the CPU.
However I ahve found that games tend to not give you a PhysX option at all without an Nvidia card, and running PhysX off the CPU gets you pretty horrible performance (which may have something to do with Nvidia hobbling PhysX on CPU it with inefficient code).
Please stop with a "inefficient code" argument. The original Ageia PhysX sepc did use X87 for the binaries that run on the CPU, but at the time, SSE wasn't a thing yet. When NVIDIA acquired Ageia in the mide 2000's (2008ish I think), they started to re-work the API, which wasn't done until about 2010 (when they broke backward compatibility with the Ageia PPU). At that point, the API used SSE rather then X87. So the inefficient code argument is a fallacy, since it hasn't been valid for about 5 years now.
Some types of Physics simulations are VERY hard to do on a CPU. Anything with fluid dynamics, multiple object interactions, or some forms of cloth simulation is VERY expensive to perform properly. They all benefit from being run on the GPU. And those are the ones that typically eat performance in games. That's why, outside of PhysX, you don't see these done realistically done at all, because they are simply too hard to do.