So sometimes one works and sometimes the other. If the game has a launcher that lets you change video settings before launching then you don't need to do either of these:
1.) Add "-window" to the launch options in Steam or in target in the .exe properties at the end of the file path. This will launch in a window, obviously, and shouldn't launch to a black screen. Change your video settings in game then once you exit it you can remove the -window.
2.) Right click the .exe > properties > compatibility> disable desktop composition. This will force windows into basic mode before it launches. I found it to work sometimes, Dead Island for example. If this trick works you will have to use it every time you run the game. I think this is when dual monitors are causing the bug, but that's just a hunch.
I hope that helps. I'd like to hear how you like that Asus.