What about 2 similar boxes, instead of trying to cram everything into one box? 8 SATA drives each.
16 drives x 3TB each - 1 each for an OS....
14 data drives = 42TB of free space.
How much 'stuff' are you looking at having?
I know it's probably more than I need, but I just want to know what I can do to connect more hard drives because right now there are only eight SATA connections on the motherboard and I know at some point I'll want more hard drives. Buying a whole new motherboard and making a second computer to just add eight more connections doesn't make sense if there is some way I can connect more hard drives to this one.