Have you identified all of the critical elements for the timing of the RAM and set them manually?
While most motherboards are validated for up to a certain speed of RAM, that is never a guarantee you can run at that speed. It's mostly a marketing point.
The most crucial part of the equation is the memory controller that is actually interfacing with the RAM, and that is on the processor.
So, what processor are you running, and what is the board? We can't offer help that is very detailed if you don't offer up a few more specifics about what you're working with.
On the Intel side of things, their newest controller, the one in Haswell, is really only spec'd on paper to run up to 1600 MHz, and AMD's controller in their FX line is only rated up to 1866 MHz. The catch with this is they are only rated for two modules on the AMD platform and four on the Intel side of things. So, trying to run with four modules at 1866 is just plain unsupported, even if you can find timings that will allow it.
Not trying to be negative, but feel you should have the best picture of what you're working with so you can plan accordingly.