Thanks for the reply. I should have said it's win7.
I run VLC, utorrent, steam, winamp, firefox, autohotkey, avast, ms word.
I've tried turning off the mouse. I've been testing it recently with a "Turn Off Monitor" exe file. The monitor will go black for 1 second and then come back on, as if the mouse were moved. This prevents the windows auto monitor sleep timer from working. Something is active in the background. The weird thing is that I will turn off almost all my programs and try and if my computers been on for a while it still won't work.
Help would be super appreciated.
and I have a asus pb278q with display port.