As long as you read the instructions on how to use it I would think that you will be fine. If it doesn't work it's not like it would damage anything it would just not work and you could either call their tech support or not use it and overclock the normal way.
Usually these things are tested at the factory before they add these features to a motherboard and the OC Genie has been a MSI feature for a while now.
Thanks for the reply. I clicked it on for a few mins. it raised my idle temp by about 5c. I am just too paranoid I guess. So long as it doesn't have a reputation for doing something wrong I feel confident with your answer! Thank you