Computer not detecting hard drives on boot up...

I've been having this problem the past month or so where around about 70% of the time my computer fails to detect either of my hard drives on start up, so far I've tried;

- A new hard drive with a clean install of Windows 7 (3 different hard drives)
- Different SATA ports with no success
- Replacing the motherboard with the same model

I've had this computer for a few years and it hasn't done this in the past, is there anything I'm overlooking?
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