maybe, but not likely.
If, once your computer is built, then it is just going to sit there undisturbed for a few years in a nice cool environment, then it is probably fine.
If you are going to be detaching and reattaching it several times then you will wear it out and break it eventually. If it is going to go through big temperature swings of getting warm and cold all of the time then it may wear out as well.
All of that said, the way I have my computer setup the 12V CPU power connector is stretched to it's limit and it has been running for 2 years without issue, but the system runs consistently cool, and I have only reattached it once in that 2 year period.