msi has some really poor AM3+ motherboards... so i generally don't suggest them... ever. as to your question, the biggest difference is the quality of the vrm/mosfets and their cooling. The asus uses high quality mosfets with ample heatsinks, the msi uses cheap ones and no heatsinks. In short you'll get better and more stable overclocking out of the Asus, and the asus likely will last longer. If you're planning on a 125W tdp fx cpu, i would highly suggest you avoid the MSI as inadequate to your needs. It will run a 95W tdp cpu just fine, with a slight overclock... but i wouldn't do more then that with it.