Hello... Ram is the most un-stable, and very sensivtive to settings, computer Part in your motherboard... But it is also the Fastest at performance at what it does... My advice is to let the motherboard and ram run together at what ever setting it likes, weather it be 1333 or 1600... if your computer BOOTs when you push the button, day after day, thats what is the most important thing... re-branding a 1333 part to 1600 is marketing practice, and compatiblity with every motherboard will vary.