Lots of programs will work just fine with Symbolic Links. I had to do that a fair bit when I was trying to juggle my first SSD with just 60GB space. It doesn't always work (iTunes, for example, will no longer be able to make iPhone backups). Lots of programs I used seem to be fine though. You can try moving it and creating the Symlink, if start to see issues with the program, just delete the sym link and move it back.