Yes, it can in theory, but if 1) the 2GB HD GPU is pcie2.1 or pcie3.0 2)the ASUS don't have the bios update for the MB then it can't. At this moment, I can't check the support website ( maybe down time), you can check it later. Because your MB has only pcie1.1, here is link amoverclock29 from overclock.net has the answer.