Yes.
I just bought a ST3000DM 3TB drive from newegg. There is no way to go back once you choose MBR and partition UNLESS you delete the MBR partition and (thankfully, i was using it as a 2nd drive) convert it to GPT using MMC Disk management. On a single drive PC that might be an issue, unless you have another PC you can put it in temporarily and make it GPT, then reinstall on your original PC.