The sapphire runs at 925 Mhz, while the Gigabyte runs at 1000mhz... not too far apart, THEY WILL WORK! But you have 2 options, Run the Sapphire as your top card and let the Gigabyte clock down to match, or run the Gigabyte as the top card and so a small OC to the Sapphire to match. You shouldn't have any issues.