I have a Dell Optiplex 380 Desktop. Running Windows 7 Professional 64 bit. I have been able to wake the system up from sleep mode using the mouse or keyboard, but can only wake from hibernate using the start button on the front of the tower. That tells me that I probably have the right selections made in the Power options and in the Device Manager. In the BIOS, I have disabled the Low Power Mode. In fact, I have tried many different combinations of settings, but to no avail. Any suggestions would be appreciated.