You need to check the CFM rating on the various fans. It would stand to reason that a 140mm fan would move more air than a 120mm at the same RPM, but that isn't always the case. If you have the 140mm fans as exhaust and the three 120mm fans as intake, you will create a positive air flow. I have a 200mm in front at the bottom for intake, a 120mm at the rear for exhaust and two 120mm at the top for exhaust. Anyway, the object is to have a good flow of air moving through the case, while at the same time, keeping it as quiet as possible.