Yes, it's no different from copying files to or from a flash drive. Many, if not most, flash drives use FAT (either FAT16 or FAT32), while most desktops and laptops use NTFS, yet there is no problem copying files between the devices. Since Windows knows and understands all the different Windows file formats (NTFS and FAT are all Windows or DOS file systems), it takes care of the details, you don't have to be concerned. It's only when copying between file systems that Windows doesn't understand, such as some Linux or the Apple file systems, that there are issues. If Windows Explorer on your computer can see the files on the drive, then they're copy-able.