Computer not powering on, possible GPU or mobo issue

Svelte Marvin

Honorable
Nov 30, 2013
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10,510
My sister-in-law is having some problems with her computer. She recently swapped out power supplies and upgraded to a new video card, and shortly thereafter her machine stopped working. We just disassembled it and tried a few things, but I can't get it to work. Unfortunately, I do not have my machine here with me, so I can't test some things I'd like to. Hopefully someone here can help me?

All issues have occurred regardless of which video card is installed, so it doesn't appear to be an issue with the card, although I may be overlooking something there.

When the machine is turned on, nothing happens. No post beep, no fan twitch, no LEDs, nada. When the video card is entirely removed, everything powers on. Her motherboard has no onboard graphics, so I can't determine if everything is functioning properly, but it does post and the LEDs and fans come on normally.

We were using a 550w PSU, so I went and swapped in a 650. Same thing happened. With GPU, nothing, without it everything seemed to work fine.

We tried plugging the GPU in to the other PCIe slot, but that didn't change anything.

Is this a bad mobo? Is there any way of determining that short of plugging everything in to a different mobo and trying all over again?
She says the exact same thing happened with her new video card, but it's back in her college dorm, and I don't have it here to test.

I'm hoping someone here has a suggestion short of buying a new mobo :(

Thanks in advance, everyone