The "S" stands for strong or something like that, and it can be overvolted to 24v to perform better than a standard 12v D5 pump. You do need a Koolance pump controller (which is ~$50) to do this though.
The vanilla 450 is your standard D5 Vario pump, and you can control the speed on the pump itself without the need for external controller, but it cannot (or at least doesnt support) be overvolted.