ilmanator, what you do depends on what you want to use for sound. But just let's review briefly.
Most mobos have an audio chip on them, and output jacks on the back panel. That is where you plug in speakers. If you have a headphone jack and mic jack on the front of your case, they are plugged into connectors on your mobo that are fed by that same audio chip.
IF you have added a modern video card to your system with an HDMI output, it carries a complication. HDMI cables can carry both video and audio signals to monitors, TV's, etc. But it can be complicated getting the audio signal from the mobo chip to the vid card. So Instead, most vid card makers put their own audio chip in the vid card and feed that chip's signal to the HDMI cable. Now comes the problem: Windows only knows how to use ONE audio output chip at a time. So many of the vid card makers with their own audio chip feeding their HDMI output port have set up their Install routines to make that audio chip the Windows default sound output device. This means that the mobo audio chip is NOT being used, so the speaker jacks on the back panel and the headphone jack on the front are dead.
Now, assuming that you WANT the audio to be fed via HDMI cable to your monitor or whatever, but you still want audio ALSO to be fed to some speakers, you need to find a way to get the audio signals from the vid card to those speakers. For that purpose, SOME video card makers with this feature also provide on the back panel of their card (next to the HDMI connector) a set of standard speaker jacks. IF you have that, plug your speakers in there, instead of on the old mobo back panel. Or, you could plug your headphones in there.
Another plan is available IF you do NOT need to have audio signals on the HDMI cable, and just want to get audio from the mobo's back panel jacks. Then you just have to change Windows' default sound output device back to the mobo's audio chip. To do this, click Start ... Control Panel ... Sounds and Audio Devices, and then choose the Audio tab. At the top where you can choose the Default Sound Playback Device, click the down-arrow beside the drop-down window and choose the mobo's audio chip, often Realtek. It should be clear which one is NOT the one on your video card. Click OK at the bottom and back out.