Actually, Nostall is wrong on this one. Technically speaking, it could work(though there will be some driver issues and things of that nature), but in all reallity, you would be much better off just using a single card.
If phys x is that important to ya, sell the 280x on ebay(with the soaringt prices, you should be able to get close to 400 bucks for it), and get a gtx 770. The performance difference is negligible, and the 770 can be picked up for about 320 right now.