I currently have the same set up(GPU and Case). I've been tweaking for about 2 weeks now. Use the 2nd GPU for your monitor output and change the fan curve on the 1st to a constant 80%. You should get good results depending on how well your cables are managed. As of now I get a max of 59C on the lower card And 68C on the upper(23C ambient). This is while running heaven benchmark on ultra with tessellation for 2 hours. As for water cooling... there are no direct fit waterblocks for this GPU yet. It is non reference.