Thats really hard to say.... The Official Site says -
"What will my Windows PC need to get SimCity running so I can build the best city in the world?
SimCity on PC will run on Windows XP, Vista, and Windows 7.
Intel players will need, minimally, a 2.0 GHz Core2Duo, while our AMD players will need at least an Athlon 64 X2 Dual-Core 4000+
At least 2GB of RAM
10 GB of hard drive space
A DVD-ROM drive
At least a 512 MB video card featuring either an NVIDIA 7800 or better, an AMD chipset of at least an ATI Radeon HD 2x00 or better, or Intel Series 4 integrated graphics or better."
Will it run on Series 2 of Intel's HD Graphics? Maybe. But thats with all the Settings at the lowest. And most likely Sub 30FPS
If anyone wants to game, You should pickup a Mid Range GPU. Intel and AMD are trying to make integrated Graphics "Better" but their still far behind.