Nope, not mission critical -- I'm only talking home storage here. There are various levels of data though. You should backup anything that you don't want to lose, that is pretty much the rule. And RAID is not backup, especially not if you are not using a RAID card. It all becomes a question of relative risk v. data value. There are things that are not worth backing up -- like things that you can easily download again. There are things that are worth some level of effort, like a ripped movie and you own the disk but it would take time to rip again, although you probably would consider that optical disk the backup. On the other end there would be things like family pictures that you want that are not duplicated anywhere (like Mom's computer). You would be wise to back that sort of data up to a free cloud site.
My point is that RAID is a bit of a safety net, but it is a net that might fail so treat it that way. It is really primarily a faster and larger storage space that can deal with a single (or even two, in RAID 6) failed drives. I've seen a number of RAID 5 arrays lose a second drive during a rebuild for a first failed drive -- and that eliminates all the data on the entire array with no chance of recovery just due to a single URE (unrecoverable read error) on the second drive.
The empty slots in a case are not a guide to storage needs.