You could use one hdmi or one display port, I would recommend using both on display port if your planning on adding a 3rd monitor later on. But otherwise that card is capable of driving 4 monitors very nicely. At 2 monitiors you should still be able to play at ultra settings, but be careful with the monitors you use, when using only two monitors. Because the center of the screen will be the bessles (frame of right side of left monitor and left frame of right monitor). So if you have a monitor like m ine, ive got a good half inch frame on the sides, times that by 2 and ive got an inch gap where the middle of the screen would be. I've tried running two displays and because of that huge gap it makes fps a pain in the arse, so I just went back to one, otherwise using 3 monitors would seem the better option.