#1. Matching CPU Socket
#2. RAM Slots and Speed
#3. PCIe x 16 - slots and lanes
#4. Form Factor to fit in Case
#5. Quality of Build
You're likely asking about #5. It depends on your budget. The motherboard is likely to be the last or second to last thing that you choose for your build, and as such, it will be limited by your budget. One of the things that is a part of the Quality of Build is the Capacitors. Some companies put in quality caps some put in junk to save money.