The Extreme is a great mobo, but unless going Tri-SLI or XFire, think it's a bit of overkill, I went Hero thinking at times I'll want to run and test in SLI/XFire (I use my rigs to test components for new client builds, upgrades and repairs), I've built on a couple of Extremes, but think they were wanted in part for bragging rights as the Hero would have done just as well (same with the Formula if you've looked at it)....I've been going primarily with a combo of an SSD (for OS and primary apps) alongside a (or multiple HDs) and occasionally the HDs paired with a pair of SSDs in RAID)....As far as OCing the CPU, you'll prob get tired of the rig before anything would happen with the CPU, I've still got a pair of Q6600's running along fine in the family that were passed to my kids and their kids that I built in early 2007, (one is running 4.0 GHz, also have a number of those out that clients still run 24/7 at 3.6 and up (the Q6600 was a 2.4 stock CPU), my 2500K is over 2 years old and has run about 4.8 and higher the whole time 24/7, have my IB 3570K running 4.7 for about a year now, and fully expect both to be running for another 3-4 or more years