Is 450W (12V1 21A - 12V2 18A) enough to run a R9 270X or a GTX 760?

For a system using a single AMD Reference Design Radeon R9 270X graphics card AMD specifies a minimum of a 500 Watt or greater system power supply. The power supply should also have a maximum combined +12 Volt continuous current rating of 30 Amps or greater and have at least two 6-pin PCI Express supplementary power connectors.

For a system using a single NVIDIA Reference Design GeForce GTX 760 graphics card NVIDIA specifies a minimum of a 500 Watt or greater system power supply that has a maximum combined +12 Volt continuous current rating of 30 Amps or greater and that has at least two 6-pin PCI Express supplementary power connectors. Some of the non-Reference Design GeForce GTX 760 cards have a single 8-pin (e.g. ASUS GTX 760 DirectCU II OC) or two 8-pin (e.g. MSI GTX 760 HAWK) or one 6-pin and one 8-pin (e.g. Gigabyte GTX 760 WindForce OC, EVGA GTX 760 SC w/ACX Cooler, MSI GTX 760 TwinFrozr Gaming) PCI Express supplementary power connectors.

Channel Well Technology GPA Series 450W (GPA450P)
• maximum combined +12 Volt continuous current rating of 30 Amps
• one 6-pin PCI Express supplementary power connector

Not sufficient for either graphics card. CWT didn't include a second 6-pin PCI Express supplementary power connector most likely because they don't think you should be running a graphics card on that PSU that requires the use of two PCI Express supplementary power connectors.