To a gegree it all depends on what you do with your rig, those that are doing imaging, video, VMs, CAD, GIS and a good amount of multi-tasking are those most likely to benefit from higher freqs,,,gaming can see a bit of a boost (a few FPS), with the Gene I'd stick to 2133 tops, might get 2400 to go at a 4x4GB setup, but wouldn't count on it carrying 32GB at 2400