Can a motherboard use two different latencies of RAM as long as each is on a separate channel?

I'm currently running 4x 2GB of Corsair XMS3 DDR3 1600MHz CAS 9-9-9-24 Dual Channel bought as two matched kits (TW3X4G1333C9A)

I've recently found the need for more RAM and have my eye on a Crucial 2x 8GB DDR3 1600MHz CAS 8-8-8-24 Ballistix Tactical kit (BLT2CP8G3D1608DT1TX0CEU)

What i want to know is if they're safe to install on the same motherboard due to different CAS even if they're in different channels.

As my plan is to remove the modules in slots 0 and 2 of my four slots replacing them with the 16GB of crucial and keep the 4GB of corsair in slots 1 and 3 so the CAS won't be mixed within the same channel, and meaning i can have 20GB rather than just 16

I've also read something about an XMP profile which isn't read by default when looking at the Crucial kit, could anyone explain this to me?

So is this upgrade possible or even wise?
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  1. Best answer
    No all ram will be set to the highest cas in this case 9-9-9-24 and then use the highest voltage between all the sticks, so if one set is 1.5v and the other is 1.6v it will set all sticks to 1.6volts.
  2. Right, so it looks like I'll be either looking for the same CAS as my corsair, going with just 16 of the crucial, or biting the bullet and grabbing more RAM of the same CAS as the crucial.
  3. If they will even play together, mixing sets of DRAM can be problematic, even the same exact sets, mixing different sets and sets of different sizes can make it even harder, best to get a single set of the full amount you want
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