You can run 2133, and your motherboard might support up to 3000. Really its a waste though. Only in the most heavily RAM intensive applications ever made would you notice a difference between like 1333Mhz RAM and 3000Mhz RAM and that will be a difference of a few seconds. On the rest of the applications, which is pretty much everything, you won't even notice a single second of difference.
You want documented ram compatibility. If you should ever have a problem, you want supported ram.
Otherwise, you risk a finger pointing battle between the ram and motherboard support sites, claiming "not my problem".
One place to check is your motherboards web site.
Look for the ram QVL list. It lists all of the ram kits that have been tested with that particular motherboard.
Sometimes the QVL list is not updated after the motherboard is released.
For more current info, go to a ram vendor's web site and access their ram selection configurator.
Enter your motherboard, and you will get a list of compatible ram kits.
While today's motherboards are more tolerant of different ram, it makes sense to buy ram that is known to work and is supported.